SLP76 Phospho (Tyr128) Antibody from BIOLEGEND

SLP76 is a cytosolic adaptor protein that functions as a substrate in the T cell receptor (TCR) activation pathway. Upon TCR engagement, SLP76 is phosphorylated on multiple residues by ZAP70, resulting in the protein being translocated to the plasma membrane and facilitating the assembly of a multi-subunit complex comprised of Vav1, Nck, ITK, and PLCγ1 that activates multiple signaling pathways. Mutation and inactivation of the phosphorylation sites results in abrogation of SLP76 activity. Tyr128 is one of three residues on the N-terminus of SLP76 which becomes phosphorylated upon TCR ligation, which initiates immune cell synapse formation. SLP76 also plays an essential role in normal T cell development, and mast cell and platelet function.