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Antigenic Specificity | Human CD23 |
Clone | EBVCS-5 |
Host Species | Mouse |
Reactive Species | human |
Isotype | IgG1, κ |
Format | Spark YG™ 593 conjugate |
Size | 25 tests |
Concentration | n/a |
Applications | Flow Cytometry (FC) |
Reviews / Ratings | If you have used this antibody, please help fellow researchers by submitting reviews to pAbmAbs and antYbuddY. |
Description | Spark YG™ 593 anti-human CD23. CD23 is a 45 kD protein, also known as Leu-20, FcεRII, IgE Fc receptor, BLAST-2, B6, and low affinity IgE receptor. It is a member of the Ig family, expressed on most mature B cells, B cells in follicular mantle (but not in proliferating germinal center cells, follicular dendritic cells, monocytes, eosinophils, Langerhans cells, and a subset of T cells (10-15% of tonsillar T cells). CD23 responds to high levels of IgE by downregulating IgE secretion. In human monocytes, CD23 triggering results in release of pro-inflammatory cytokines including TNF-α, IL-1, IL-6, and GM-CSF. CD23 can be proteolytically cleaved to generate soluble CD23 fragments of various molecular weights. In chronic lymphocytic leukemia, levels of soluble CD23 in the serum can be used as a prognostic marker to identify patients at high risk for disease progression. Alternate splicing of exon 2 can also generate two cell-surface isoforms of CD23 differing by 6 amino acids in their cytoplasmic region. |
Immunogen | n/a |
Other Names | Leu-20, FcεRII, IgE Fc Receptor, BLAST-2, B6, Low affinity IgE receptor |
Gene, Accession # | Gene ID: 2208 |
Catalog # | 338531 |
Price | $147 |
Order / More Info | Human CD23 Antibody from BIOLEGEND |
Product Specific References | n/a |