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Antigenic Specificity | Human CD272 (BTLA ) |
Clone | W21076A |
Host Species | Rat |
Reactive Species | human |
Isotype | IgG2b, κ |
Format | purified, azide-free, low-endotoxin |
Size | 100 µg |
Concentration | n/a |
Applications | Block |
Reviews / Ratings | If you have used this antibody, please help fellow researchers by submitting reviews to pAbmAbs and antYbuddY. |
Description | Ultra-LEAF™ Purified anti-human CD272 (BTLA ). BTLA (B and T lymphocyte attenuator, CD272) is a type I transmembrane glycoprotein with four extracellular cysteine-rich domains. It is an inhibitory molecule structurally and functionally similar to cytotoxic T lymphocyte antigen-4 (CTLA-4) and programmed death-1 (PD-1). These molecules belong to the immunoglobulin superfamily that binds B7 family members. Different from CTLA-4 and PD-1 binding with the B7 family members, BTLA interacts with herpes virus entry mediator (HVEM/TNFRSF14) which belongs to TNFR family. BTLA/HVEM interaction was the first demonstration of crosstalk between these two family members. BTLA/HVEM interaction limits T cell activity in vivo and regulates the homeostatic expansion of CD4+ and CD8+ T cells. BTLA/HVEM interaction negatively modulates T cell activation. HVEM induces BTLA tyrosine phosphorylation and inhibits T-cell proliferation. There is accumulating evidence suggesting that BTLA/HVEM signaling also plays an important role in autoimmunity and infection at mucosal surfaces. The BTLA/HVEM interaction does not prevent the simultaneous binding of other HVEM ligands such as LIGHT/TNFSF14 or Lymphotoxin-alpha. BTLA is expressed on T cells, B cells, macrophages, dendritic cells, and natural killer cells. Constitutive expression level of BTLA on resting T cells are very low, but increase after the activation of T cells. BTLA is highly expressed on resting B cells. |
Immunogen | Recombinant human CD272 (BTLA) |
Other Names | CD272, B- and T-lymphocyte attenuator, B- and T-lymphocyte-associated protein |
Gene, Accession # | Gene ID: 151888 |
Catalog # | 622053 |
Price | $345 |
Order / More Info | Human CD272 (BTLA ) Antibody from BIOLEGEND |
Product Specific References | n/a |