Aph-1a, 245-265 (C terminus) Antibody from BIOLEGEND
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| Antigenic Specificity | Aph-1a, 245-265 (C terminus) |
| Clone | polyclonal |
| Host Species | Rabbit |
| Reactive Species | human |
| Isotype | n/a |
| Format | purified, azide-free |
| Size | 100 µL |
| Concentration | n/a |
| Applications | Western Blot (WB), ICC |
| Reviews / Ratings | If you have used this antibody, please help fellow researchers by submitting reviews to pAbmAbs and antYbuddY. |
| Description | Purified (azide-free) anti-Aph-1a, 245-265 (C terminus). The gamma secretase is a multiprotein complex consisting of presenilin, nicastrin, Aph-1 and Pen-2; all four proteins are necessary for full proteolytic activity. The gamma secretase complex catalyzes cleavage of a number of integral membrane proteins including Amyloid precursor protein, Notch, Erb4 and E-cadherin. While Aph-1 stabilizes the presenilin holoprotein within the gamma secretase complex, Pen-2 is required for endoproteolysis of presenilin and activation of the gamma secretase. The Ap |
| Immunogen | The antibody Aph-1a, 245-265 (Poly18231) was raised against the human Aph-1aL/C-terminal region and recognizes the sequence CRRQEDSRVMVYSALRIPPED of human Aph-1aL. |
| Other Names | Gamma-secretase subunit APH-1A, aph-1alpha, presenilin-stabilization factor, CGI-78, anterior pharynx defective 1 homolog A, presenilin-stabilization factor |
| Gene, Accession # | Gene ID: 51107 |
| Catalog # | 823101 |
| Price | $448 |
| Order / More Info | Aph-1a, 245-265 (C terminus) Antibody from BIOLEGEND |
| Product Specific References | PubMed: 27835671 |
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