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Antigenic Specificity | 4EBP1 Phospho (Thr70) |
Clone | A18010A |
Host Species | Mouse |
Reactive Species | human, mouse |
Isotype | IgG1, κ |
Format | purified |
Size | 25 µg |
Concentration | n/a |
Applications | Western Blot (WB) |
Reviews / Ratings | If you have used this antibody, please help fellow researchers by submitting reviews to pAbmAbs and antYbuddY. |
Description | Purified anti-4EBP1 Phospho (Thr70). In eukaryotes, the mTOR kinase signaling pathway links cell growth and proliferation with nutrient availability. Under nutrient-deplete conditions, eukaryotic translation initiations factor 4E-binding protein 1 (4EBP1) binds the general translation factor eIF4E, resulting in an attenuation of cap-dependent translation. Under nutrient-replete conditions, mTORC1 and mTORC2 complexes phosphorylate 4EBP1 at Threonine 70 and disrupt the formation of the 4EBP1-eIF4E complex, thereby alleviating the re |
Immunogen | Synthetic peptide corresponding to human 4EBP1 phosphorylated at Threonine 70 |
Other Names | Eukaryotic Translation Initiation Factor 4E Binding Protein 1, Phosphorylated Heat- And Acid-Stable Protein Regulated By Insulin 1, PHAS-I |
Gene, Accession # | Gene ID: 1978 |
Catalog # | 619601 |
Price | $112 |
Order / More Info | 4EBP1 Phospho (Thr70) Antibody from BIOLEGEND |
Product Specific References | n/a |