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Antigenic Specificity | Mouse FOXP3 |
Clone | QA20A67 |
Host Species | Recombinant Rat |
Reactive Species | mouse |
Isotype | IgG1, κ |
Format | Alexa Fluor® 647 conjugate |
Size | 25 µg |
Concentration | n/a |
Applications | Intracellular Staining for Flow Cytometry (ICFC) |
Reviews / Ratings | If you have used this antibody, please help fellow researchers by submitting reviews to pAbmAbs and antYbuddY. |
Description | Alexa Fluor® 647 anti-mouse FOXP3 Recombinant. FOXP3, also known as Forkhead box protein P3, Scurfin, JM2, or IPEX, is a 47 kD transcription factor. It is proposed to be a master regulatory gene and more specific marker of T regulatory cells than most cell surface markers (such as CD4 and CD25). Transduced expression of FOXP3 in CD4+/CD25- cells has been shown to induce GITR, CD103, and CTLA4 and impart a T regulatory cell phenotype. FOXP3 is mutated in X-linked autoimmunity-allergic dysregulation syndrome (XLAAD or IPEX) in humans and in "scurfy" mice. Overexpression of FOXP3 has been shown to lead to a hypoactive immune state suggesting that this transcriptional factor is a central regulator of T cell activity. |
Immunogen | n/a |
Other Names | Forkhead box protein P3, Scurfin, JM2, IPEX, Zinc finger protein JM2 |
Gene, Accession # | Gene ID: 20371 |
Catalog # | 118905 |
Price | $195 |
Order / More Info | Mouse FOXP3 Antibody from BIOLEGEND |
Product Specific References | n/a |