Vimentin Antibody from BIOLEGEND

Vimentin are class-III intermediate filaments found in various non-epithelial cells, especially mesenchymal cells. Vimentin is a widely expressed and highly conserved 54 kD protein that is constitutively expressed in mesenchymal cells, endothelial cells lining blood vessels, renal tubular cells, macrophages, neutrophils, fibroblasts, and leukocytes^1,2. Vimentin is used as a marker of mesenchymal cells to distinguish them from epithelial cells³. Increased vimentin expression is frequently used as an EMT marker in cancer⁴. Autoantibodies to vimentin are commonly found in patients with autoimmune diseases such as Lupus⁵ and rheumatoid arthritis⁶, and also found after transplantation⁷.