Description | PE anti-T-bet. T-bet, also known as T-box transcription factor T-bet, is considered to be a "master regulator" of Th1 lymphoid development controlling the production of the cytokine IFN-γ. T-bet is widely expressed in hematopoietic cells including stem cells, NK cells, B cells, and T cells. T-bet is critical for the control of microbial pathogens, and knockout animals show multiple physiologic and inflammatory features characteristic of asthma. T-bet expression is optimally observed after IL-12 stimulation and |
Product Specific References | PubMed: 27284976, 28084312, 29038474, 29022922, 29491374, 29262349, 30420782, 31533030, 30772378, 30709740, 29129787, 28895840, 29262349, 31120033, 32142650, 31810882, 31924474, 32091410, 33207209, 33296702, 33434494, 33894129, 33852868 |