SIRT1 Antibody from BIOLEGEND
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| Antigenic Specificity | SIRT1 |
| Clone | W16003A |
| Host Species | Rat |
| Reactive Species | human, mouse |
| Isotype | IgG2a, κ |
| Format | purified |
| Size | 100 µg |
| Concentration | n/a |
| Applications | Western Blot (WB), KO/KD-Western Blot (WB) |
| Reviews / Ratings | If you have used this antibody, please help fellow researchers by submitting reviews to pAbmAbs and antYbuddY. |
| Description | Purified anti-SIRT1. SIRT1, the human homolog of the S. cerevisiae Sir2 protein, functions as an NAD-dependent deacetylase of a number of nonhistone substrates including p53. In response to DNA damage, SIRT1 binds and deacetylates the p53 protein at c-terminal Lys382 residue and attenuates p53-mediated functions. When overexpressed in mouse embryo fibroblasts, SIRT1 antagonizes PML-induced acetylation of p53 and rescues PML-mediated premature cellular senescence. In mammalian cells, SIRT1 appears to control the cell |
| Immunogen | Partial human SIRT1 recombinant protein (548-747 a.a.) expressed in E. coli. |
| Other Names | NAD-dependent deacetylase sirtuin-1, SIR2-like protein 1 (SIR2L1), Regulatory protein SIR2 homolog 1, hSIRT1, hSIR2 |
| Gene, Accession # | Gene ID: 23411 |
| Catalog # | 690502 |
| Price | $253 |
| Order / More Info | SIRT1 Antibody from BIOLEGEND |
| Product Specific References | n/a |
BIOLEGEND
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