Sun2 Antibody from BIOLEGEND

Sun2 is a transmembrane protein that localizes to the inner nuclear membrane and interacts with other nuclear proteins to form the LINC (Linker of Nucleoskeleton and Cytoskeleton) complex. This complex bridges the nuclear envelope, connecting the nuclear lamina to the cytoskeleton, thereby providing mechanical support and stability to the nucleus. Sun2 also plays a vital role in nuclear migration, chromosome organization, and gene regulation. Additionally, Sun2 is involved in maintaining nuclear envelope integrity during cell division and DNA repair, and has been suggested to act as a tumor suppressor by protecting against cancer-inducing DNA damage. In lung cancer, Sun2 has been shown to inhibit the Warburg effect via Glut1 and LDHA.