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Antigenic Specificity | Human TNF-α |
Clone | W19063E |
Host Species | Rat |
Reactive Species | human |
Isotype | IgG1, κ |
Format | Brilliant Violet 650™ conjugate |
Size | 25 tests |
Concentration | n/a |
Applications | Intracellular Staining for Flow Cytometry (ICFC) |
Reviews / Ratings | If you have used this antibody, please help fellow researchers by submitting reviews to pAbmAbs and antYbuddY. |
Description | Brilliant Violet 650™ anti-human TNF-α. TNF-α is secreted by macrophages, monocytes, neutrophils, T cells (principally CD4+), and NK cells. Many transformed cell lines also secrete TNF-α. Monomeric human TNF-α is a 157 amino acid protein (non-glycosylated) with a reported molecular weight of 17 kD. TNF-α forms multimeric complexes; stable trimers are most common in solution. A 26 kD membrane form of TNF-α has also been described. TNF-α binding to surface receptors elicits a wide array of biological activities including: cytolysis and cytostasis of many tumor cell lines in vitro, hemorraghic necrosis of tumors in vivo, increased fibroblast proliferation, and enhanced chemotaxis and phagocytosis in neutrophils. |
Immunogen | n/a |
Other Names | Tumor necrosis factor-α, Cachectin, Necrosin, Macrophage cytotoxic factor (MCF), Differentiation inducing factor (DIF), TNFSF2 |
Gene, Accession # | Gene ID: 7124 |
Catalog # | 376211 |
Price | $135 |
Order / More Info | Human TNF-α Antibody from BIOLEGEND |
Product Specific References | n/a |