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Antigenic Specificity | IREB2 |
Clone | W18260A |
Host Species | Rat |
Reactive Species | human |
Isotype | IgG2a, λ |
Format | purified |
Size | 25 µg |
Concentration | n/a |
Applications | Western Blot (WB), IHC-P, IP |
Reviews / Ratings | If you have used this antibody, please help fellow researchers by submitting reviews to pAbmAbs and antYbuddY. |
Description | Purified anti-IREB2. IREB2 is an iron-responsive protein that regulates a cell's levels of iron, a key micronutrient. In low-iron situations, IREB2 is free to bind to iron-responsive elements in mRNA molecules, stabilizing transferrin mRNA to increase expression of the iron uptake receptor, while blocking the translation of ferritin mRNA, a protein which sequesters excess iron molecules. However, when sufficient iron levels are present, IREB2 undergoes a conformation change to lose its mRNA binding ability, resultin |
Immunogen | Recombinant fragment of human IREB2 |
Other Names | Iron-responsive element-binding protein 2 (IRE-BP 2, IREB2), Iron Regulatory Protein 2 (IRP2) |
Gene, Accession # | Gene ID: 3658 |
Catalog # | 608951 |
Price | $155 |
Order / More Info | IREB2 Antibody from BIOLEGEND |
Product Specific References | n/a |