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Antigenic Specificity | Human DKK-1 |
Clone | W19278B |
Host Species | Mouse |
Reactive Species | human |
Isotype | IgG2b, κ |
Format | purified |
Size | 100 µg |
Concentration | n/a |
Applications | Direct ELISA |
Reviews / Ratings | If you have used this antibody, please help fellow researchers by submitting reviews to pAbmAbs and antYbuddY. |
Description | Purified anti-human DKK-1. DKK-1 (Dickkopf related protein 1) is a member of the Dickkopf family of proteins that include DKK-1, -2, -3, -4, and Soggy. DKK-1 was discovered by its ability to block Wnt signaling during early Xenopus embryogenesis. DKK-1 antagonizes canonical Wnt signaling by inhibiting LRP5/6 interaction with Wnt proteins. DKK-1 forms a ternary complex with LRP5/6 and the transmembrane protein Kremen1/2, promoting internalization of LRP5/6 and down regulation of Wnt signaling. DKK-1 contains two conserved |
Immunogen | Human Recombinant DKK-1 Protein |
Other Names | Dickkopf-related protein 1, DKK1, Dickkopf WNT signaling pathway inhibitor 1 |
Gene, Accession # | Gene ID: 22943 |
Catalog # | 616552 |
Price | $265 |
Order / More Info | Human DKK-1 Antibody from BIOLEGEND |
Product Specific References | n/a |