CD326 (EpCAM) Antibody from BIOLEGEND

CD326 is also known as EpCAM (Epithelial cell adhesion molecule), a glycosylated I transmembrane protein containing six disulfide bridges and one THYRO domain. It is highly expressed in bone marrow, colon, lung, and most normal epithelial cells where it functions as an adhesion molecule. In addition to cell adhesion, CD326 is also involved in cellular signaling, cell migration, proliferation, and differentiation. Recently, it has been reported that CD326 expression occurs during the early steps of erythrogenesis. CD326 functions as a homotypic calcium-independent cell adhesion molecule and is involved in carcinogenesis via its ability to induce genes c-myc, e-fabp, and cyclins A & E involved in cellular metabolism and proliferation. Research studies have demonstrated that CD326 plays a role in tumorigenesis and metastasis of carcinomas, therefore, has the potential to serve as a prognostic marker and an immunotherapeutic target.