BRTC1/2 Antibody from BIORBYT LTD.
Search, find, compare suppliers for anti-BRTC1/2 antibody, protein, ELISA kits.
| Edit | |
|---|---|
| Antigenic Specificity | BRTC1/2 |
| Clone | polyclonal |
| Host Species | Rabbit |
| Reactive Species | human |
| Isotype | n/a |
| Format | unconjugated |
| Size | 400 ul, 80 ul |
| Concentration | n/a |
| Applications | WB |
| Reviews / Ratings | If you have used this antibody, please help fellow researchers by submitting reviews to pAbmAbs and antYbuddY. |
| Description | Rabbit polyclonal to BRTC1/2. Substrate recognition component of a SCF (SKP1-CUL1-F-box protein) E3 ubiquitin-protein ligase complex which mediates the ubiquitination and subsequent proteasomal degradation of target proteins. Recognizes and binds to phosphorylated target proteins. SCF(BTRC) mediates the ubiquitination of CTNNB1 and participates in Wnt signaling. SCF(BTRC) mediates the ubiquitination of NFKBIA, NFKBIB and NFKBIE; the degradation frees the associated NFKB1 to translocate into the nucleus and to activate transcription. Ubiquitination of NFKBIA occurs at Lys-21 and Lys-22. SCF(BTRC) mediates the ubiquitination of phosphorylated NFKB1/nuclear factor NF-kappa-B p105 subunit, ATF4, SMAD3, SMAD4, CDC25A, DLG1, FBXO5 and probably NFKB2. SCF(BTRC) mediates the ubiquitination of phosphorylated SNAI1. May be involved in ubiquitination and subsequent proteasomal degradation through a DBB1-CUL4 E3 ubiquitin-protein ligase. Required for activation of NFKB-mediated transcription by IL1B, MAP3K14, MAP3K1, IKBKB and TNF. Required for proteolytic processing of GLI3. |
| Immunogen | Synthetic Peptide |
| Other Names | BTRC, BTRCP, FBW1A, FBXW1A, F-box/WD repeat-containing protein 1A, F-box/WD repeat-containing protein 1A, E3RSIkappaB, F-box/WD repeat-containing protein 1A, Epididymis tissue protein Li 2a, F-box/WD repeat-containing protein 1A, F-box and WD repeats protein beta-TrCP, F-box/WD repeat-containing protein 1A, pIkappaBalpha-E3 receptor subunit |
| Gene, Accession # | UniProt: Q9Y297 |
| Catalog # | orb134924 |
| Price | $561 |
| Order / More Info | BRTC1/2 Antibody from BIORBYT LTD. |
| Product Specific References | n/a |
BIORBYT LTD.
BIORBYT LTD.
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