B7-H3 / CD276 Antibody from BIORBYT LTD.
Search, find, compare suppliers for anti-B7-H3 / CD276 antibody, protein, ELISA kits.
| Edit | |
|---|---|
| Antigenic Specificity | B7-H3 / CD276 |
| Clone | B7H3/4348 |
| Host Species | Mouse |
| Reactive Species | human |
| Isotype | IgG2b, kappa |
| Format | unconjugated |
| Size | 20 ug |
| Concentration | n/a |
| Applications | IHC-P |
| Reviews / Ratings | If you have used this antibody, please help fellow researchers by submitting reviews to pAbmAbs and antYbuddY. |
| Description | T cell activation and immune function are regulated by the innate immune system through positive and negative costimulatory molecules. One such molecule, B7-H3 (B7-homolog 3, also designated B7RP-2 and CD276) belongs to the B7 immunoglobulin superfamily. Soluble B7-H3 binds a putative receptor on activated T-cells that is distinct from CD28, CTLA-4, ICOS and PD-1. Widely expressed on nonlymphoid tissues, B7-H3 costimulates proliferation of both CD4+ and CD8+ T cells. The ability of B7-H3 to stimulate Th1 and cytotoxic-T cell responses suggest that it may have antitumor activity. B7-H3 interactions may play a role in regulating cell-mediated immune responses against cancer, implicating B7-H3 as a potential therapeutic tool. |
| Immunogen | A portion of amino acids 100-300 from the human CD276 protein was used as the immunogen for the B7-H3 antibody. |
| Other Names | n/a |
| Gene, Accession # | UniProt: Q5ZPR3 |
| Catalog # | orb1716146 |
| Price | $405 |
| Order / More Info | B7-H3 / CD276 Antibody from BIORBYT LTD. |
| Product Specific References | n/a |
BIORBYT LTD.
BIORBYT LTD.
7 Signet Court
Swann Road
Cambridge, CB5 8LA U.K.
P: +44 (0)1223 859 353
F: +44(0)1223 280 240
info@biorbyt.com
http://www.biorbyt.com
U.S. OFFICE
Biorbyt LLC
1100 Corporate Square Drive
Helix Center, Suite 221
St Louis, MO 63132
Email: info@biorbyt.com
Phone: +1 (415) 906-5211
Fax: +1 (415) 651-8558
Profile of BIORBYT LTD.
Return to Antibodies