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Antigenic Specificity | Langerin / CD207 |
Clone | LGRN/7429 |
Host Species | Mouse |
Reactive Species | human |
Isotype | IgG |
Format | unconjugated |
Size | 20 ug |
Concentration | n/a |
Applications | IHC-P |
Reviews / Ratings | If you have used this antibody, please help fellow researchers by submitting reviews to pAbmAbs and antYbuddY. |
Description | Langerhans cells (LCs) are a subset of immature dendritic cells (DCs) that specifically localize in the epidermis and other mucosal epithelia. Epidermal LCs possess strong immuno-stimulatory capacity and play a central role in the initiation and regulation of immune responses. Langerin (CD207) is a Ca2+-dependent, C-type lectin domain containing, type II transmembrane protein that induces epidermal LCs to differentiate into Birbeck granules (BG). BGs are organelles with superimposing and zippering membranes that influence proper class I type antigen presentation to the circulating T cells. Human spleen, lymph node, thymus, liver, lung and heart express Langerin protein. |
Immunogen | A recombinant partial protein sequence (within amino acids 50-250) from the human protein was used as the immunogen for the CD207 antibody. |
Other Names | n/a |
Gene, Accession # | UniProt: Q9UJ71 |
Catalog # | orb1823952 |
Price | $405 |
Order / More Info | Langerin / CD207 Antibody from BIORBYT LTD. |
Product Specific References | n/a |
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