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Antigenic Specificity | A2M / Alpha-2-Macroglobulin |
Clone | A2M/6554 |
Host Species | Mouse |
Reactive Species | human |
Isotype | IgG2c, kappa |
Format | unconjugated |
Size | 100 ug |
Concentration | n/a |
Applications | IHC-P |
Reviews / Ratings | If you have used this antibody, please help fellow researchers by submitting reviews to pAbmAbs and antYbuddY. |
Description | Alpha-2-Macroglobulin (Alpha-2M) is a homotetrameric serum protein consisting of four identical subunits that form dimers through disulfide bonds. Initially, Alpha-2M was characterized as a pan-proteinase inhibitor that was able to bait proteinases into cleaving specific peptide sequences on Alpha-2M. This interaction induces a conformational change in Alpha-2M, thus enabling it to trap the proteinase and further inhibit its activity. Subsequently, Alpha-2M has been shown to function as a carrier protein and regulator of cytokines during inflammation. Circulating transforming growth factor beta (TGFbeta) in serum is primarily bound to Alpha-2M, which renders TGFbeta inactive. Alpha-2M also binds to IL-6 and, thereby, increases the concentration of IL-6 near lymphocytes, hepatocytes and stem cells involved in mediating the inflammatory cascade. Mutations and deletions in the gene encoding Alpha-2M are associated with an increased incidence of Alzheimer s disease (AD), which is consistent with the role of Alpha-2M in mediating the clearance and degradation of A beta, the major component of beta-Amyloid deposits accumulated during AD. |
Immunogen | A recombinant partial protein within amino acids 604-748 from the human protein was used as the immunogen for the A2M antibody. |
Other Names | n/a |
Gene, Accession # | UniProt: P01023 |
Catalog # | orb1825840 |
Price | $764 |
Order / More Info | A2M / Alpha-2-Macroglobulin Antibody from BIORBYT LTD. |
Product Specific References | n/a |
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