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Antigenic Specificity | B7-H3 / CD276 |
Clone | B7H3/4345 |
Host Species | Mouse |
Reactive Species | human |
Isotype | IgG1, kappa |
Format | unconjugated |
Size | 20 ug |
Concentration | n/a |
Applications | IHC-P |
Reviews / Ratings | If you have used this antibody, please help fellow researchers by submitting reviews to pAbmAbs and antYbuddY. |
Description | T cell activation and immune function are regulated by the innate immune system through positive and negative costimulatory molecules. One such molecule, B7-H3 (B7-homolog 3, also designated B7RP-2 and CD276) belongs to the B7 immunoglobulin superfamily. Soluble B7-H3/CD276 binds a putative receptor on activated T-cells that is distinct from CD28, CTLA-4, ICOS and PD-1. Widely expressed on nonlymphoid tissues, it costimulates proliferation of both CD4+ and CD8+ T cells. The ability of B7-H3/CD276 to stimulate Th1 and cytotoxic-T cell responses suggest that it may have antitumor activity. B7-H3 interactions may play a role in regulating cell-mediated immune responses against cancer, implicating B7-H3/CD276 as a potential therapeutic tool. |
Immunogen | A portion of amino acids 100-300 from the human CD276 protein was used as the immunogen for the CD276 antibody. |
Other Names | n/a |
Gene, Accession # | UniProt: Q5ZPR3 |
Catalog # | orb1716188 |
Price | $405 |
Order / More Info | B7-H3 / CD276 Antibody from BIORBYT LTD. |
Product Specific References | n/a |
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