SOD1 (EDI) Antibody from BIORBYT LTD.
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| Antigenic Specificity | SOD1 (EDI) |
| Clone | polyclonal |
| Host Species | Rabbit |
| Reactive Species | human, mouse, porcine, rat |
| Isotype | n/a |
| Format | alkaline phosphatase (AP) conjugate |
| Size | 100 ug |
| Concentration | 1 mg/ml |
| Applications | ELISA, IHC, WB |
| Reviews / Ratings | If you have used this antibody, please help fellow researchers by submitting reviews to pAbmAbs and antYbuddY. |
| Description | Rabbit polyclonal to SOD1 (Alkaline Phosphatase). Superoxide dismutase (SOD) is an endogenously produced intracellular enzyme present in almost every cell in the body. It works by catalyzing the dismutation of the superoxide radical O2 to O2 and H2O2, which are then metabolized to H2O and O2 by catalase and glutathione peroxidase (1,4). In general, SODs play a major role in antioxidant defense mechanisms. There are two main types of SOD in mammalian cells. One form (SOD1) contains Cu and Zn ions as a homodimer and exists in the cytoplasm. The two subunits of 16 kDa each are linked by two cysteines forming an intra-subunit disulphide bridge. Misfolding of SOD1 has been implicated in Amyotrophic lateral sclerosis (ALS). Therefore conformation specific antibodies such as SOD1 (EDI), which targets an exposed region of the dimer interface (EDI) of SOD1, are useful for determining the conformation of SOD1 in affected tissues. This antibody can be used in conjunction with SOD1 (U beta B) (SPC-205D) which detects an unfolded beta barrel (U beta B) of SOD1.. |
| Immunogen | C-terminal region of SOD1, exposed dimer interface (EDI) |
| Other Names | SEDI, SOD1 EDI, Superoxide dismutase 1, SOD, SOD1 exposed dimer interface |
| Gene, Accession # | Gene ID: 6647, UniProt: P00441 |
| Catalog # | orb152270 |
| Price | $532 |
| Order / More Info | SOD1 (EDI) Antibody from BIORBYT LTD. |
| Product Specific References | n/a |
BIORBYT LTD.
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