Cyclin B1 / CCNB1 Antibody from BIORBYT LTD.
Search, find, compare suppliers for anti-Cyclin B1 / CCNB1 antibody, protein, ELISA kits.
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| Antigenic Specificity | Cyclin B1 / CCNB1 |
| Clone | SPM619 |
| Host Species | Mouse |
| Reactive Species | human |
| Isotype | IgG1, kappa |
| Format | Protein G purified |
| Size | 20 ug, 100 ug |
| Concentration | n/a |
| Applications | IF, IHC-P |
| Reviews / Ratings | If you have used this antibody, please help fellow researchers by submitting reviews to pAbmAbs and antYbuddY. |
| Description | It recognizes a protein of 55-62kDa, identified as cyclin B1. In mammals, cyclin B associates with inactive p34cdc2, which facilitates phosphorylation of p34cdc2 at aa 14Thr and 15Tyr. This maintains the inactive state until the end of G2-phase. The inactive cyclin B-p34cdc2 complex continues to accumulate in the cytoplasm until the completion of DNA synthesis, when Cdc25, a specific protein phosphatase, dephosphorylates aa 14Thr and 15Tyr of p34cdc2 rendering the complex active at the G2/M boundary. This mitotic kinase complex remains active until the metaphase/anaphase transition when cyclin B is degraded. This degradation process is ubiquitin-dependent and is necessary for the cell to exit mitosis. So, cyclin B-p34cdc2 plays a critical role in G2 to M transition. |
| Immunogen | Recombinant human full-length protein was used as the immunogen for the CCNB1 antibody. |
| Other Names | n/a |
| Gene, Accession # | UniProt: P14635 |
| Catalog # | orb749863 |
| Price | $405 |
| Order / More Info | Cyclin B1 / CCNB1 Antibody from BIORBYT LTD. |
| Product Specific References | n/a |
BIORBYT LTD.
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