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Antigenic Specificity | CD22 |
Clone | MYG13 |
Host Species | Mouse |
Reactive Species | human, mouse, rat |
Isotype | IgG1, kappa |
Format | Protein G purified |
Size | 100 ug, 20 ug |
Concentration | n/a |
Applications | FACS |
Reviews / Ratings | If you have used this antibody, please help fellow researchers by submitting reviews to pAbmAbs and antYbuddY. |
Description | Recognizes a protein of 130-140 kDa, identified as CD22 (also known as BL-CAM). CD22 expression is restricted to normal and neoplastic B cells and is absent from other haemopoietic cell types. In B-cell ontogeny, CD22 is first expressed in the cytoplasm of pro-B and pre-B cells, and on the surface as B cells mature to become IgD+. It is not expressed by plasma cells, CD22 is found highly expressed in follicular mantle and marginal zone B-cells, and while germinal center B-cells are relatively weak. CD22 is a member of the immunoglobulin superfamily and serves as an adhesion receptor for sialic acid-bearing ligands expressed on erythrocytes and all leukocyte classes. It also associates with tyrosine kinases and play a role in signal transduction and B-cell activation. |
Immunogen | Human Raji cells were used as the immunogen for the CD22 antibody. |
Other Names | n/a |
Gene, Accession # | UniProt: P20273 |
Catalog # | orb749880 |
Price | $764 |
Order / More Info | CD22 Antibody from BIORBYT LTD. |
Product Specific References | n/a |
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