MECA-79 / Peripheral Node Addressin / PNAd Antibody from BIORBYT LTD.
Search, find, compare suppliers for anti-MECA-79 / Peripheral Node Addressin / PNAd antibody, protein, ELISA kits.
| Edit | |
|---|---|
| Antigenic Specificity | MECA-79 / Peripheral Node Addressin / PNAd |
| Clone | MECA-79 |
| Host Species | Rat |
| Reactive Species | human, mouse, rat |
| Isotype | IgM, kappa |
| Format | Protein G purified |
| Size | 20 ug, 100 ug |
| Concentration | n/a |
| Applications | FACS, IF, IHC-P, WB |
| Reviews / Ratings | If you have used this antibody, please help fellow researchers by submitting reviews to pAbmAbs and antYbuddY. |
| Description | MECA-79 recognizes a carbohydrate epitope shared with a group of sulfation decorated sialomucins, including sulfated ligands for CD62L (CD34, GlyCAM-1, Sgp200, and a subset of MAdCAM-1). This set antigens has been referred to as peripheral node addressin (PNAd) with the molecular mass 50-250 kD. It has been identified that GlcNAc-6-SO4 sulfation contributes to MECA-79 binding and the core 1 beta1,3-N-acetylglucosaminyltransferase is required for the generation of the MECA-79 epitope. MECA-79 is expressed on high endothelial venules (HEV) of lymphoid tissues, chronic inflamed tissues and rheumatoid synovia. The interaction of PNAd with CD62L receptor is involved in tethering and rolling of lymphocytes along HEV in lymphoid tissues. MECA-79 antibody reacts with Mouse, human and many other species PNAd and blocks L-selectin-dependent lymphocyte adhesion in vitro and in vivo. |
| Immunogen | Mouse lymph node stromal cells were used as the immunogen for this MECA-79 antibody. |
| Other Names | n/a |
| Gene, Accession # | n/a |
| Catalog # | orb640134 |
| Price | $405 |
| Order / More Info | MECA-79 / Peripheral Node Addressin / PNAd Antibody from BIORBYT LTD. |
| Product Specific References | n/a |
BIORBYT LTD.
BIORBYT LTD.
7 Signet Court
Swann Road
Cambridge, CB5 8LA U.K.
P: +44 (0)1223 859 353
F: +44(0)1223 280 240
info@biorbyt.com
http://www.biorbyt.com
U.S. OFFICE
Biorbyt LLC
1100 Corporate Square Drive
Helix Center, Suite 221
St Louis, MO 63132
Email: info@biorbyt.com
Phone: +1 (415) 906-5211
Fax: +1 (415) 651-8558
Profile of BIORBYT LTD.
Return to Antibodies