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Antigenic Specificity | MYCN |
Clone | PCRP-MYCN-1A9 |
Host Species | Mouse |
Reactive Species | human |
Isotype | IgG1 |
Format | unconjugated |
Size | 100 ug |
Concentration | n/a |
Applications | ELISA, FACS |
Reviews / Ratings | If you have used this antibody, please help fellow researchers by submitting reviews to pAbmAbs and antYbuddY. |
Description | The v-Myc oncogene, initially identified in the MC29 avian retrovirus, causes myelocytomas, carcinomas, sarcomas and lymphomas, and belongs to a family of oncogenes conserved throughout evolution. In humans, the family consists of five genes: c-Myc, N-Myc, R-Myc, L-Myc and B-Myc. Amplification of the N-Myc gene has been found in human neuroblastomas and cell lines. Its amplification correlates well with the stage of neuroblastoma disease. Immunological studies have shown that the human N-Myc gene encodes a nuclear phosphoprotein that exhibits relatively short (30 min) half life in vivo. The prototype member of the family, c-Myc p67, binds DNA in a sequence-specific manner subsequent to dimerization with a second basic region helix-loop-helix leucine zipper motif protein, designated Max. |
Immunogen | A recombinant human MYCN protein (within amino acids 335-463) was used as the immunogen for the MYCN antibody. |
Other Names | n/a |
Gene, Accession # | UniProt: P04198 |
Catalog # | orb1823905 |
Price | $764 |
Order / More Info | MYCN Antibody from BIORBYT LTD. |
Product Specific References | n/a |
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