TNF alpha Antibody from BIORBYT LTD.
Search, find, compare suppliers for anti-TNF alpha antibody, protein, ELISA kits.
| Edit | |
|---|---|
| Antigenic Specificity | TNF alpha |
| Clone | TMDa1-1 |
| Host Species | Mouse |
| Reactive Species | human, rat |
| Isotype | IgM, kappa |
| Format | PEG purified |
| Size | 100 ug, 20 ug |
| Concentration | n/a |
| Applications | FACS, IF, IHC-P |
| Reviews / Ratings | If you have used this antibody, please help fellow researchers by submitting reviews to pAbmAbs and antYbuddY. |
| Description | Tumor Necrosis Factor Alpha (TNF alpha) is a cytokine that binds to TNFRSF1A/TNFR1 and TNFRSF1B/TNFBR. It is mainly secreted by macrophages and can induce cell death of certain tumor cell lines. It is potent pyrogen causing fever by direct action or by stimulation of interleukin-1 secretion and is implicated in the induction of cachexia, Under certain conditions it can stimulate cell proliferation and induce cell differentiation. Impairs regulatory T-cells (Treg) function in individuals with rheumatoid arthritis via FOXP3 dephosphorylation. Upregulates the expression of protein phosphatase 1 (PP1), which dephosphorylates the key 'Ser-418' residue of FOXP3, thereby inactivating FOXP3 and rendering Treg cells functionally defective. Key mediator of cell death in the anticancer action of BCG-stimulated neutrophils in combination with DIABLO/SMAC mimetic in the RT4v6 bladder cancer cell line. [UniProt] |
| Immunogen | Full length human recombinant protein was used as the immunogen for the TNF alpha antibody. |
| Other Names | n/a |
| Gene, Accession # | UniProt: P01375 |
| Catalog # | orb385905 |
| Price | $764 |
| Order / More Info | TNF alpha Antibody from BIORBYT LTD. |
| Product Specific References | n/a |
BIORBYT LTD.
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