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Antigenic Specificity | n-Myc |
Clone | NMYC-1 |
Host Species | Mouse |
Reactive Species | human, mouse, rat |
Isotype | IgG2a, kappa |
Format | Protein G purified |
Size | 20 ug, 100 ug |
Concentration | n/a |
Applications | IF, WB |
Reviews / Ratings | If you have used this antibody, please help fellow researchers by submitting reviews to pAbmAbs and antYbuddY. |
Description | The v-Myc oncogene, initially identified in the MC29 avian retrovirus, causes myelocytomas, carcinomas, sarcomas and lymphomas, and belongs to a family of oncogenes conserved throughout evolution. In humans, the family consists of five genes: c-Myc, N-Myc, R-Myc, L-Myc and B-Myc. Amplification of the N-Myc gene has been found in human neuroblastomas and cell lines. Its amplification correlates well with the stage of neuroblastoma disease. Immunological studies have shown that the human N-Myc gene encodes a nuclear phosphoprotein that exhibits relatively short (30 min) half life in vivo. The prototype member of the family, c-Myc p67, binds DNA in a sequence-specific manner subsequent to dimerization with a second basic region helix-loop-helix leucine zipper motif protein, designated Max. |
Immunogen | A recombinant full-length human n-Myc protein was used as the immunogen for the n-Myc antibody. |
Other Names | n/a |
Gene, Accession # | UniProt: P04198 |
Catalog # | orb639825 |
Price | $405 |
Order / More Info | n-Myc Antibody from BIORBYT LTD. |
Product Specific References | n/a |
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