TGFB3 / TGF beta 3 Antibody from BIORBYT LTD.
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| Edit | |
|---|---|
| Antigenic Specificity | TGFB3 / TGF beta 3 |
| Clone | TGFB3/4801 |
| Host Species | Mouse |
| Reactive Species | human |
| Isotype | IgG2, kappa |
| Format | unconjugated |
| Size | 100 ug |
| Concentration | n/a |
| Applications | IHC-P |
| Reviews / Ratings | If you have used this antibody, please help fellow researchers by submitting reviews to pAbmAbs and antYbuddY. |
| Description | Transforming growth factor betas (TGF-betas) were originally discovered due to their ability to promote anchorage-independent growth of rat NRK fibroblasts in the presence of TGF-beta. TGF-beta 1, TGF-beta 2 and TGF-beta 3 are each synthesized as precursor proteins that are very similar in that each is cleaved to yield a 112 amino acid polypeptide that remains associated with the latent portion of the molecules. TGF-beta 3 mediates many intercellular interactions that occur during embryonic development, cell differentiation and epithelial homeostasis. TGF-beta 3 overexpresses in extramammary Paget s disease (EPD) and downregulates in Bowen s disease, indicating that its expression is a useful indicator of tumor activity. TGF-beta 3 levels strongly correlate with IGF-1 and osteocalcin levels in serum. Significant amounts of TGF-beta 3 circulation appear to be representative of TGFbeta 3 expression in bone and may in part be derived from bone. Glucocorticoids may block TGF-beta production by modulating mRNA levels and c-Jun activity. |
| Immunogen | A recombinant partial protein sequence (within amino acids 50-250) from the human protein was used as the immunogen for the TGF beta 3 antibody. |
| Other Names | n/a |
| Gene, Accession # | UniProt: P10600 |
| Catalog # | orb1825519 |
| Price | $764 |
| Order / More Info | TGFB3 / TGF beta 3 Antibody from BIORBYT LTD. |
| Product Specific References | n/a |
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