Pellino 1 Antibody from BIORBYT LTD.
Search, find, compare suppliers for anti-Pellino 1 antibody, protein, ELISA kits.
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| Antigenic Specificity | Pellino 1 |
| Clone | monoclonal |
| Host Species | Rabbit |
| Reactive Species | human, rat |
| Isotype | IgG |
| Format | unconjugated |
| Size | 100 ul |
| Concentration | 1mg/ml |
| Applications | IP, WB |
| Reviews / Ratings | If you have used this antibody, please help fellow researchers by submitting reviews to pAbmAbs and antYbuddY. |
| Description | E3 ubiquitin ligase catalyzing the covalent attachment of ubiquitin moieties onto substrate proteins. Involved in the TLR and IL-1 signaling pathways via interaction with the complex containing IRAK kinases and TRAF6. Mediates 'Lys-63'-linked polyubiquitination of IRAK1 allowing subsequent NF-kappa-B activation (PubMed:12496252, PubMed:17675297). Mediates 'Lys-48'-linked polyubiquitination of RIPK3 leading to its subsequent proteasome-dependent degradation; preferentially recognizes and mediates the degradation of the 'Thr-182' phosphorylated form of RIPK3 (PubMed:29883609). Negatively regulates necroptosis by reducing RIPK3 expression (PubMed:29883609). Mediates 'Lys-63'-linked ubiquitination of RIPK1 (PubMed:29883609). |
| Immunogen | Recombinant protein of human Pellino 1 |
| Other Names | Pellino-related intracellular-signaling molecule; RING-type E3 ubiquitin transferase pellino homolog 1 |
| Gene, Accession # | Gene ID: 57162, UniProt: Q96FA3 |
| Catalog # | orb1731540 |
| Price | $345 |
| Order / More Info | Pellino 1 Antibody from BIORBYT LTD. |
| Product Specific References | n/a |
BIORBYT LTD.
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