Edit |   |
---|---|
Antigenic Specificity | IL17A |
Clone | polyclonal |
Host Species | n/a |
Reactive Species | human |
Isotype | n/a |
Format | unconjugated |
Size | 200 ul, 100 ul, 50 ul |
Concentration | n/a |
Applications | WB |
Reviews / Ratings | If you have used this antibody, please help fellow researchers by submitting reviews to pAbmAbs and antYbuddY. |
Description | Rabbit polyclonal to IL17A.IL-17A is a cystine-linked homodimeric pro-inflammatory cytokine produced by Th17 cells, a distinct CD4+ T cell lineage. IL-17A stimulates the production of the pro-inflammatory cytokines IL-1beta, TNF-alpha, and IL-6. IL-17A also induces production of the neutrophil chemoattractants IL-8, CXCL1, and CXCL6 thereby bridging adaptive and innate immunity. IL-17A is intimately involved in mucosal immunity against bacterial infections and has a putative role in some autoimmune disorders. IL-17A effects appear to be exerted primarily through binding to the IL-17RA. IL-17A binding induces production of cytokines, chemokines and other proteins through activation of the Erk1/2 MAP kinase, PI3K/Akt, p38, and NF-kB pathways. |
Immunogen | Recombinant fusion protein of human IL17A(NP_002181.1). |
Other Names | IL17A, CTLA8, IL-17, IL-17A, IL17 |
Gene, Accession # | UniProt: Q16552 |
Catalog # | orb48920 |
Price | $490 |
Order / More Info | IL17A Antibody from BIORBYT LTD. |
Product Specific References | n/a |
U.S. OFFICE
Biorbyt LLC
1100 Corporate Square Drive
Helix Center, Suite 221
St Louis, MO 63132
Email: info@biorbyt.com
Phone: +1 (415) 906-5211
Fax: +1 (415) 651-8558