Bcl6 Antibody from BIORBYT LTD.
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| Edit | |
|---|---|
| Antigenic Specificity | Bcl6 |
| Clone | BCL6/2497R |
| Host Species | Recombinant Rabbit |
| Reactive Species | human |
| Isotype | IgG, kappa |
| Format | Protein A purified |
| Size | 20 ug, 100 ug |
| Concentration | n/a |
| Applications | IHC-P |
| Reviews / Ratings | If you have used this antibody, please help fellow researchers by submitting reviews to pAbmAbs and antYbuddY. |
| Description | Recognizes a protein of 95kDa, which is identified as Bcl-6. Antibody to bcl-6 is helpful in a number of diagnostic settings: (1) In the differential diagnosis of small B-cell lymphoma. Follicular lymphoma will show bcl-6 (and CD10) positivity whereas other small B-cell lymphomas are usually negative. (2) Bcl-6 is an important prognostic marker in diffuse large B-cell lymphomas (DLBCL), where CD10, bcl-6 and MUM1/IRF4 are used to identify germinal center and activated B-cell phenotypes. (3) Bcl-6 can be valuable in distinguishing classical Hodgkin lymphoma from nodular lymphocyte predominant Hodgkin lymphoma (NLPHL). The Reed-Sternberg cells of classical Hodgkin lymphoma are bcl-6 negative whereas the large ('LH') cells of NLPHL are bcl-6 positive. In contrast, anti-Bcl-6 rarely stains mantle-cell lymphoma and MALT lymphoma. |
| Immunogen | A recombinant human partial protein (amino acids 256-389) was used as the immunogen for this recombinant Bcl6 antibody. |
| Other Names | n/a |
| Gene, Accession # | UniProt: P41182 |
| Catalog # | orb639909 |
| Price | $405 |
| Order / More Info | Bcl6 Antibody from BIORBYT LTD. |
| Product Specific References | n/a |
BIORBYT LTD.
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