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Antigenic Specificity | CD105 |
Clone | MEM-229 |
Host Species | Mouse |
Reactive Species | human, porcine |
Isotype | IgG2a |
Format | allophycocyanin (APC) conjugate |
Size | 100 tests |
Concentration | n/a |
Applications | FC |
Reviews / Ratings | If you have used this antibody, please help fellow researchers by submitting reviews to pAbmAbs and antYbuddY. |
Description | CD105 (endoglin) is a homodimeric transmembrane glycoprotein serving in presence of TGFbetaR-2 as a receptor for TGFbeta-1 and TGFbeta-3. CD105 is highly expressed on endothelial cells and promotes angiogenesis during wound healing, infarcts and in a wide range of tumours and its gene expression is stimulated by hypoxia. CD105 prevents apoptosis in hypoxic endothelial cells and also antagonises the inhibitory effects of TGFbeta-1 on vascular endothelial cell growth and migration. Normal cellular levels of CD105 are required for formation of new blood vessels. |
Immunogen | Recombinant Vaccinia virus containing the human CD105 (L-isoform) cDNA. |
Other Names | Endoglin, END, ENG, HHT1, ORW1 |
Gene, Accession # | UniProt: P17813, Gene ID: 2022 |
Catalog # | orb1909791 |
Price | $439 |
Order / More Info | CD105 Antibody from BIORBYT LTD. |
Product Specific References | n/a |
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