TrkB / NTRK2 Antibody from BIORBYT LTD.
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| Antigenic Specificity | TrkB / NTRK2 |
| Clone | NTRK2/7928 |
| Host Species | Mouse |
| Reactive Species | human |
| Isotype | IgG2, lambda |
| Format | unconjugated |
| Size | 20 ug |
| Concentration | n/a |
| Applications | IHC-P |
| Reviews / Ratings | If you have used this antibody, please help fellow researchers by submitting reviews to pAbmAbs and antYbuddY. |
| Description | The Trk proto-oncogene encodes a tyrosine protein kinase, Trk A, also designated Trk gp140, that serves as a receptor for certain neurotrophic factors including nerve growth factor (NGF) and neurotrophin-3 (NT-3). Trk B is a tyrosine kinase gene highly related to Trk A. The brain-derived neurotrophic factor (BDNF) and NT-3, but not NGF, can induce rapid phosphorylation on tyrosine of Trk B gp145, one of the receptors encoded by NTRK2, although BDNF elicits a response at least two orders of magnitude greater than NT-3. Thus it appears that Trk B gp145 may represent a neurotrophic receptor for BDNF and NT-3. The third member of the Trk family of tyrosine kinases, Trk C, encodes a protein designated Trk C gp145 that is preferentially expressed in brain tissue, is equally related to Trk A and Trk B and is a functional receptor for NT-3. |
| Immunogen | A recombinant partial protein sequence (within amino acids 250-450) from the human protein was used as the immunogen for the TrkB antibody. |
| Other Names | n/a |
| Gene, Accession # | UniProt: Q16620 |
| Catalog # | orb1822722 |
| Price | $405 |
| Order / More Info | TrkB / NTRK2 Antibody from BIORBYT LTD. |
| Product Specific References | n/a |
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