Copper Transporting ATPase 1 Antibody from BIORBYT LTD.
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| Antigenic Specificity | Copper Transporting ATPase 1 |
| Clone | S60-4 |
| Host Species | Mouse |
| Reactive Species | human, mouse, rat |
| Isotype | IgG2b |
| Format | ATTO-390 conjugate |
| Size | 100 ug |
| Concentration | 1 mg/ml |
| Applications | ICC, IHC, IP, WB |
| Reviews / Ratings | If you have used this antibody, please help fellow researchers by submitting reviews to pAbmAbs and antYbuddY. |
| Description | Mouse monoclonal to Copper Transporting ATPase 1 (ATTO-390). The copper efflux transporters ATP7A and ATP7B sequester intracellular copper into the vesicular secretory pathway for export from the cell. ATP7A (also known as Copper-transporting ATPase 1) functions as a transmembrane copper-trans locating P-type ATPase and plays a vital role in systemic copper absorption in the gut and copper reabsorption in the kidney. Polarized epithelial cells such as Madin-Darby canine kidney cells are a physiologically relevant model for systemic copper absorption and reabsorption in vivo. Although ATP7A is not detectable in most normal tissues, it is expressed in a considerable fraction of many common tumor types. Increased expression of ATP7A renders cells resistant to cisplatin and carboplatin. Mutations in the ATP7A gene result in Menkes disease, which is fatal in early childhood. Mutations in the ATP7B gene lead to the autosomal recessive disorder, Wilson disease, characterized by neurological symptoms and hepatic damage.. |
| Immunogen | Synthetic peptide amino acids 42-61 (cytoplasmic C-terminus) of human Copper- transporting ATPase1 |
| Other Names | ATP7A, ATP 7A, ATPase Cu transporting, DSMAX, FLJ17790, MC1, MC 1, MK, MNK, OHS, Copper pump 1, Menke, OTTHUMP00000062077, SMAX3, ATPase copper transporting alpha polypeptide, ATPase Cu++ transporting alpha polypeptide (Menkes syndrome), Copper transporting ATPase 1, Cu++ transporting P type ATPase, Menkes disease associated protein, Menkes syndrome |
| Gene, Accession # | Gene ID: 538, UniProt: Q04656 |
| Catalog # | orb149783 |
| Price | $575 |
| Order / More Info | Copper Transporting ATPase 1 Antibody from BIORBYT LTD. |
| Product Specific References | n/a |
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