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Antigenic Specificity | CD63 / LAMP-3 |
Clone | LAMP3/3315 |
Host Species | Mouse |
Reactive Species | human |
Isotype | IgG2b, kappa |
Format | Protein G purified |
Size | 20 ug, 100 ug |
Concentration | n/a |
Applications | IHC-P |
Reviews / Ratings | If you have used this antibody, please help fellow researchers by submitting reviews to pAbmAbs and antYbuddY. |
Description | This MAb recognizes protein of 26kDa-60kDa, which is identified as CD63. The tetraspanins are integral membrane proteins expressed on cell surface and granular membranes of hematopoietic cells and are components of multi-molecular complexes with specific integrins. The tetraspanin CD63 is a lysosomal membrane glycoprotein that translocates to the plasma membrane after platelet activation. CD63 is expressed on activated platelets, monocytes and macrophages, and is weakly expressed on granulocytes, T cell and B cells. It is located on the basophilic granule membranes and on the plasma membranes of lymphocytes and granulocytes. CD63 is a member of the TM4 superfamily of leukocyte glycoproteins that includes CD9, CD37 and CD53, which contain four transmembrane regions. CD63 may play a role in phagocytic and intracellular lysosome-phagosome fusion events. CD63 deficiency is associated with Hermansky-Pudlak syndrome and is strongly expressed during the early stages of melanoma progression. |
Immunogen | A portion of amino acids 100-197 from the human protein was used as the immunogen for the CD63 antibody. |
Other Names | n/a |
Gene, Accession # | UniProt: P08962 |
Catalog # | orb699536 |
Price | $405 |
Order / More Info | CD63 / LAMP-3 Antibody from BIORBYT LTD. |
Product Specific References | n/a |
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