GFI1B Antibody from BIORBYT LTD.
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|---|---|
| Antigenic Specificity | GFI1B |
| Clone | RB44051 |
| Host Species | Rabbit |
| Reactive Species | human, mouse |
| Isotype | n/a |
| Format | unconjugated |
| Size | 400 ul, 80 ul |
| Concentration | n/a |
| Applications | WB |
| Reviews / Ratings | If you have used this antibody, please help fellow researchers by submitting reviews to pAbmAbs and antYbuddY. |
| Description | Rabbit polyclonal to GFI1B. Essential proto-oncogenic transcriptional regulator necessary for development and differentiation of erythroid and megakaryocytic lineages. Component of a RCOR-GFI-KDM1A-HDAC complex that suppresses, via histone deacetylase (HDAC) recruitment, a number of genes implicated in multilineage blood cell development and controls hematopoietic differentiation. Transcriptional repressor or activator depending on both promoter and cell type context; represses promoter activity of SOCS1 and SOCS3 and thus, may regulate cytokine signaling pathways. Cooperates with GATA1 to repress target gene transcription, such as the apoptosis regulator BCL2L1; GFI1B silencing in leukemic cell lines markedly increase apoptosis rate. Inhibits down-regulation of MYC and MYB as well as the cyclin-dependent kinase inhibitor CDKN1A/P21WAF1 in IL6-treated myelomonocytic cells. Represses expression of GATA3 in T-cell lymphomas and inhibits GATA1-mediated transcription; as GATA1 also mediates erythroid GFI1B transcription, both GATA1 and GFI1B participate in a feedback regulatory pathway controlling the expression of GFI1B gene in erythroid cells. Suppresses GATA1-mediated stimulation of GFI1B promoter through protein interaction. Binds to gamma-satellite DNA and to its own promoter, auto-repressing its own expression. Alters histone methylation by recruiting histone methyltransferase to target genes promoters. Plays a role in heterochromatin formation. |
| Immunogen | Synthetic Peptide |
| Other Names | Zinc finger protein Gfi-1b, Zinc finger protein Gfi-1b, Zinc finger protein Gfi-1b, Growth factor independent protein 1B, Zinc finger protein Gfi-1b, Potential regulator of CDKN1A translocated in CML |
| Gene, Accession # | UniProt: Q5VTD9 |
| Catalog # | orb107035 |
| Price | $561 |
| Order / More Info | GFI1B Antibody from BIORBYT LTD. |
| Product Specific References | n/a |
BIORBYT LTD.
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