FOXP3 / Scurfin Antibody from BIORBYT LTD.
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| Antigenic Specificity | FOXP3 / Scurfin |
| Clone | FOXP3/8145R |
| Host Species | Recombinant Rabbit |
| Reactive Species | human |
| Isotype | IgG, kappa |
| Format | unconjugated |
| Size | 20 ug |
| Concentration | n/a |
| Applications | IHC-P |
| Reviews / Ratings | If you have used this antibody, please help fellow researchers by submitting reviews to pAbmAbs and antYbuddY. |
| Description | The FOX family of transcription factors is a large group of proteins that share a common DNA binding domain termed a winged-helix or forkhead domain. During early development, FOXP1 and FOXP2 are expressed abundantly in the lung, with lower levels of expression in neural, intestinal and cardiovascular tissues, where they act as transcription repressors. FOXP1 is widely expressed in adult tissues, while neoplastic cells often exhibit a dramatic change in expression level or localization of FOXP1. Mutations in FOXP3 gene cause IPEX, a fatal, X-linked inherited disorder characterized by immune dysregulation. The FOXP3 protein is essential for normal immune homeostasis. Specifically, FOXP3 represses transcription through a DNA binding forkhead domain, thereby regulating T cell activation. |
| Immunogen | A recombinant partial protein sequence (within amino acids 300-431) from the human protein was used as the immunogen for the Scurfin antibody. |
| Other Names | n/a |
| Gene, Accession # | UniProt: Q9BZS1 |
| Catalog # | orb1822620 |
| Price | $405 |
| Order / More Info | FOXP3 / Scurfin Antibody from BIORBYT LTD. |
| Product Specific References | n/a |
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