Cytokeratin 14 / CK14 / KRT14 Antibody from BIORBYT LTD.
Search, find, compare suppliers for anti-Cytokeratin 14 / CK14 / KRT14 antibody, protein, ELISA kits.
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|---|---|
| Antigenic Specificity | Cytokeratin 14 / CK14 / KRT14 |
| Clone | rKRT14/7368 |
| Host Species | Recombinant Mouse |
| Reactive Species | human |
| Isotype | IgG1, kappa |
| Format | unconjugated |
| Size | 100 ug |
| Concentration | n/a |
| Applications | IHC-P |
| Reviews / Ratings | If you have used this antibody, please help fellow researchers by submitting reviews to pAbmAbs and antYbuddY. |
| Description | Cytokeratin 14 is a member of the type I keratin family of intermediate filament proteins. It always pairs with the type II keratin K5 and form the primary keratin pair of the keratinocytes of stratified squamous epithelia, including the epidermis as well as mucosal non-keratinizing stratified squamous epithelia.Cytokeratin 14 is strongly expressed in the undifferentiated basal cell layer containing the stem cells and are down-regulated in the differentiating suprabasal cell layers. Otherwise, in the widely well stratified follicular outer root sheath, cytokeratin 14 is uniformly expressed throughout all layers. The expression spectrum of cytokeratin 14 in tumors corresponds well to the patterns in normal epithelia. Thus, most squamous cell carcinomas as well as malignant mesotheliomas strongly express this keratin whereas little, focal, or no expression is found in adenocarcinomas.Cytokeratin 14 may be a useful marker in the differential diagnosis of squamous cell carcinoma from other epithelial tumors. Recent studies also indicate that CK14 expression in breast cancer corresponded with poor clinical outcome and that CK14 may have diagnostic value in the sub-classification of NSCLC. |
| Immunogen | A recombinant human KRT14 fragment (within amino acids 350-472) was used as the immunogen for the recombinant KRT14 antibody. |
| Other Names | n/a |
| Gene, Accession # | UniProt: P02533 |
| Catalog # | orb1825150 |
| Price | $764 |
| Order / More Info | Cytokeratin 14 / CK14 / KRT14 Antibody from BIORBYT LTD. |
| Product Specific References | n/a |
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