Clostridium difficile Toxin A Antibody from BIORBYT LTD.
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|---|---|
| Antigenic Specificity | Clostridium difficile Toxin A |
| Clone | 253/422 |
| Host Species | Mouse |
| Reactive Species | n/a |
| Isotype | IgG1, kappa |
| Format | Protein G purified |
| Size | 20 ug, 100 ug |
| Concentration | n/a |
| Applications | ELISA, IF |
| Reviews / Ratings | If you have used this antibody, please help fellow researchers by submitting reviews to pAbmAbs and antYbuddY. |
| Description | This mAb reacts with C. difficile Toxin A, but not with Cholera subunit a, Cholera toxin, Pseudomonas aeruginosa exotoxin A, H-LT, P-LT. Clostridium difficile is a major nosocomial pathogen that causes antibiotic- associated colitis. Clostridium difficile mediates inflammatory diarrhea by releasing two large protein enterotoxins (Toxin A and Toxin B) that are able to disrupt intestinal epithelial cells via their transferase activity and ability to monoglucosylate members of the Rho family. Clostridium difficile Toxin A is a toxin that is composed of 39 repeats that are responsible for binding to intestinal epithelial cell surface carbohydrates. Clostridium difficile Toxin A causes significant apoptosis of colonocytes which contributes to the formation of ulcers and pseudo-membranes in a pathway that involves p38-dependent activation of p53 and induction of p21, leading to cytochrome c release and caspase-3 activation through Bak activation. |
| Immunogen | C. difficile Toxin A was used as the immunogen for the Clostridium difficile Toxin A antibody. |
| Other Names | n/a |
| Gene, Accession # | UniProt: P16154 |
| Catalog # | orb640085 |
| Price | $405 |
| Order / More Info | Clostridium difficile Toxin A Antibody from BIORBYT LTD. |
| Product Specific References | n/a |
BIORBYT LTD.
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