JAK2 Antibody from BIORBYT LTD.
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| Antigenic Specificity | JAK2 |
| Clone | polyclonal |
| Host Species | Rabbit |
| Reactive Species | human, mouse, porcine, primate, rabbit, rat |
| Isotype | n/a |
| Format | unconjugated |
| Size | 200 ul, 100 ul, 30 ul |
| Concentration | n/a |
| Applications | IF, IH, WB |
| Reviews / Ratings | If you have used this antibody, please help fellow researchers by submitting reviews to pAbmAbs and antYbuddY. |
| Description | Rabbit polyclonal antibody to JAK2 also known as JAK-2 whose expression can be detected in whole-body tissues ubiquitously. It is found in the extrinsic component of the nucleus. It can perform various functions like MAPK cascade mechanism and histone H3-Y41 phosphorylation. In the nucleus it plays a key role in chromatin by specifically mediating phosphorylation of 'Tyr-41' of histone H3 (H3Y41ph), a specific tag that promotes the exclusion of CBX5 (HP1 alpha) from chromatin. In the cytoplasm, it plays a pivotal role in signal transduction via its association with type I receptors such as growth hormone (GHR), prolactin (PRLR), leptin (LEPR), erythropoietin (EPOR), thrombopoietin (THPO); or type II receptors including IFN-alpha, IFN-beta, IFN-gamma and multiple interleukins. |
| Immunogen | KLH-conjugated synthetic peptide encompassing a sequence within the center region of human JAK2. The exact sequence is proprietary. |
| Other Names | Tyrosine-protein kinase JAK2, Janus kinase 2, JAK-2 |
| Gene, Accession # | Gene ID: 3717, UniProt: Q62120 |
| Catalog # | orb318917 |
| Price | $337 |
| Order / More Info | JAK2 Antibody from BIORBYT LTD. |
| Product Specific References | n/a |
BIORBYT LTD.
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