C3d / Complement 3d Antibody from BIORBYT LTD.
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| Antigenic Specificity | C3d / Complement 3d |
| Clone | C3D/2891 |
| Host Species | Mouse |
| Reactive Species | human |
| Isotype | IgG2b, kappa |
| Format | Protein G purified |
| Size | 100 ug, 20 ug |
| Concentration | n/a |
| Applications | IHC-P |
| Reviews / Ratings | If you have used this antibody, please help fellow researchers by submitting reviews to pAbmAbs and antYbuddY. |
| Description | The complement component proteins, C2, C3, C4 and C5, are potent anaphylatoxins that are released during complement activation. Binding of these proteins to their respective G protein-coupled receptors, C3aR, C1R and C5aR, induces proinflammatory events, such as cellular degranulation, smooth muscle contraction, arachidonic acid metabolism, cytokine release, leukocyte activation and cellular chemotaxis. C3d is a terminal degradation product of C3 that plays an important role in modulation of the adaptive immune response through the interaction with complement receptor type 2 (CR2). CR2 is important in the switched-isotype, high-affinity and memory humoral immune responses to T-dependent foreign antigens, as well as in the development of the natural antibody repertoire. This pH- and ionic strength-dependent association of C3d with CR2 represents a link between innate and adaptive immunity. |
| Immunogen | A portion of amino acids 1250-1450 from human Complement C3 protein was used as the immunogen for this Complement 3d antibody. |
| Other Names | n/a |
| Gene, Accession # | UniProt: P01024 |
| Catalog # | orb639977 |
| Price | $764 |
| Order / More Info | C3d / Complement 3d Antibody from BIORBYT LTD. |
| Product Specific References | n/a |
BIORBYT LTD.
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