GCLM / Glutamate-Cysteine Ligase Regulatory Subunit Antibody from BIORBYT LTD.
Search, find, compare suppliers for anti-GCLM / Glutamate-Cysteine Ligase Regulatory Subunit antibody, protein, ELISA kits.
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| Antigenic Specificity | GCLM / Glutamate-Cysteine Ligase Regulatory Subunit |
| Clone | GCLM/4069 |
| Host Species | Mouse |
| Reactive Species | human |
| Isotype | IgG2a, kappa |
| Format | unconjugated |
| Size | 20 ug |
| Concentration | n/a |
| Applications | IHC-P |
| Reviews / Ratings | If you have used this antibody, please help fellow researchers by submitting reviews to pAbmAbs and antYbuddY. |
| Description | g-glutamylcysteine synthetase (g-GCS) is the rate limiting enzyme for glutathione (L-g-glutamyl-L-cysteinylglycine, GSH) synthesis. GSH is ubiquitous in mammalian cells as a vital intra- and extracellular protective antioxidant. g-GCS is a heterodimer of a heavy catalytic subunit and a light regulatory subunit that is responsive to inflammation, phenolic antioxidants, heat shock, oxidants and cytokines. The human g-GCS gene encoding the 367 amino acid catalytic subunit maps to chromosome 6p12. The human g-GCS gene encoding the regulatory subunit maps to chromosome 1p22.1. The two subunits of g-GCS form a heterodimeric zinc metalloprotein that gains activity through formation of a reversible disulfide bond. |
| Immunogen | Recombinant full-length human GLCLR protein was used as the immunogen for the GCLM antibody. |
| Other Names | n/a |
| Gene, Accession # | UniProt: P48507 |
| Catalog # | orb1824609 |
| Price | $405 |
| Order / More Info | GCLM / Glutamate-Cysteine Ligase Regulatory Subunit Antibody from BIORBYT LTD. |
| Product Specific References | n/a |
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