Notch1 Antibody from BIORBYT LTD.
Search, find, compare suppliers for anti-Notch1 antibody, protein, ELISA kits.
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|---|---|
| Antigenic Specificity | Notch1 |
| Clone | S253-32 |
| Host Species | Mouse |
| Reactive Species | human, mouse, rat |
| Isotype | IgG1 |
| Format | ATTO-594 conjugate |
| Size | 100 ug |
| Concentration | 1 mg/ml |
| Applications | ICC, WB |
| Reviews / Ratings | If you have used this antibody, please help fellow researchers by submitting reviews to pAbmAbs and antYbuddY. |
| Description | Mouse monoclonal to Notch1 (ATTO-594). Notch is synthesized in the endoplasmic reticulum as an inactive form which is proteolytically cleaved by a furin-like convertase (S1 cleavage) in the trans-golgi network before it reaches the plasma membrane to yield an active, ligand-accessible form. Cleavage results in a C-terminal fragment N(TM) and a N-terminal fragment N(EC). Following ligand binding, it is cleaved (S2 cleavage) by TNF-alpha converting enzyme (TACE) to yield a membrane-associated intermediate fragment called Notch extracellular truncation (NEXT). This fragment is then cleaved by presenilin-dependent gamma-secretase (S3 cleavage) to release the intracellular domain (NICD) from the membrane.. |
| Immunogen | Fusion protein amino acids 20-216 (extracellular N-terminus, EGF-like domains 1-5) of mouse Notch1 |
| Other Names | Neurogenic locus notch homolog protein 1, hN1, Translocation associated notch protein, TAN1, TAN-1, Motch A, mT14, p300, Motch, Mis6, Neurogenic locus notch protein homolog, NICD, Notch 1 intracellular domain, Notch gene homolog 1 (Drosophila), Notch homolog 1, translocation-associated (Drosophila), NOTCH Drosophila, homolog of 1, Translocation associated notch homolog, Translocation associated notch protein TAN 1, xotch |
| Gene, Accession # | Gene ID: 18128, UniProt: Q01705 |
| Catalog # | orb150330 |
| Price | $573 |
| Order / More Info | Notch1 Antibody from BIORBYT LTD. |
| Product Specific References | n/a |
BIORBYT LTD.
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