PAX6 Antibody from BIORBYT LTD.
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|---|---|
| Antigenic Specificity | PAX6 |
| Clone | PAX6/8578R |
| Host Species | Recombinant Rabbit |
| Reactive Species | human |
| Isotype | IgG, kappa |
| Format | unconjugated |
| Size | 20 ug |
| Concentration | n/a |
| Applications | IHC-P |
| Reviews / Ratings | If you have used this antibody, please help fellow researchers by submitting reviews to pAbmAbs and antYbuddY. |
| Description | Pax genes contain paired domains with strong homology to genes in Drosophila, which are involved in programming early development. Lesions in the Pax-6 gene account for most cases of aniridia, a congenital malformation of the eye, chiefly characterized by iris hypoplasia, which can cause blindness. Pax-6 is involved in other anterior segment malformations besides aniridia, such as Peters anomaly, a major error in the embryonic development of the eye with corneal clouding with variable iridolenticulocorneal adhesions. The Pax-6 gene encodes a transcriptional regulator that recognizes target genes through its paired-type DNA-binding domain. The paired domain is composed of two distinct DNA-binding subdomains, the amino-terminal subdomain and the carboxy-terminal subdomain, which bind respective consensus DNA sequences. The human Pax-6 gene produces two alternatively spliced isoforms that have the distinct structure of the paired domain. |
| Immunogen | A recombinant partial protein (within amino acids 1-300) from the human protein was used as the immunogen for the PAX6 antibody. |
| Other Names | n/a |
| Gene, Accession # | UniProt: P26367 |
| Catalog # | orb1826133 |
| Price | $405 |
| Order / More Info | PAX6 Antibody from BIORBYT LTD. |
| Product Specific References | n/a |
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