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Antigenic Specificity | BRAF |
Clone | polyclonal |
Host Species | n/a |
Reactive Species | human, mouse, rat |
Isotype | n/a |
Format | unconjugated |
Size | 200 ul, 100 ul, 50 ul |
Concentration | n/a |
Applications | IHC, WB |
Reviews / Ratings | If you have used this antibody, please help fellow researchers by submitting reviews to pAbmAbs and antYbuddY. |
Description | Rabbit polyclonal antibody to BRAF. B-Raf, also know as c-Rmil, is a Serine/Threonine protein kinase member of the Raf family which includes Raf-1 and A-Raf. B-Raf is involved in the transduction of mitogenic signals from the cell membrane to the nucleus. Composed of three conserved region (CR1, CR2, CR3) B-Raf is expressed primarily in the brain and in the nervous system. It has been observed that MAPK is activated by B-Raf in response to nerve growth factor. More than 60% of malignant melanomas were found to contain a specific mutation, B-Raf (V599E) the product of which possesses constitutive kinase activity. Mutations in B-Raf have also been identified in lung cancer and non-Hodgkin lymphoma. |
Immunogen | Recombinant fusion protein of human B-Raf(NP_004324.2). |
Other Names | B-RAF1, BRAF1, NS7, RAFB1, Proto-oncogeneB-Raf, p94, v-Raf murine sarcoma viral oncogene homolog B1 |
Gene, Accession # | UniProt: P15056 |
Catalog # | orb153753 |
Price | $490 |
Order / More Info | BRAF Antibody from BIORBYT LTD. |
Product Specific References | n/a |
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