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Antigenic Specificity | Perlecan (Large) |
Clone | SPM255 |
Host Species | Rat |
Reactive Species | human |
Isotype | IgG2a, kappa |
Format | Protein G purified |
Size | 20 ug, 100 ug |
Concentration | n/a |
Applications | IHC-P |
Reviews / Ratings | If you have used this antibody, please help fellow researchers by submitting reviews to pAbmAbs and antYbuddY. |
Description | This mAb specifically precipitates heterogeneous material of high MW, identified as perlecan, a major heparan-sulfate proteoglycan (HSPG) within all basement membranes and cell surfaces. It does not cross-react with laminin, fibronectin, or dermatran sulfate proteoglycan. Because of perlecan s strategic location and ability to store and protect growth factors, it has been strongly implicated in the control of tumor cell growth and metastatic behavior. Perlecan possesses angiogenic and growth-promoting attributes primarily by acting as a co-receptor for basic fibroblast growth factor (FGF-2). Suppression of perlecan causes substantial inhibition of neoplastic growth and neovascularization. Thus, perlecan is a potent inducer of neoplasm growth and angiogenesis in vivo and therapeutic interventions targeting this key modulator of tumor progression may improve neoplastic treatment. |
Immunogen | A murine EHS laminin preparation was used as the immunogen for the anti-Perlecan antibody. |
Other Names | n/a |
Gene, Accession # | UniProt: P98160 |
Catalog # | orb749578 |
Price | $405 |
Order / More Info | Perlecan (Large) Antibody from BIORBYT LTD. |
Product Specific References | n/a |
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