ARFGEF2 Antibody from BIORBYT LTD.
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| Antigenic Specificity | ARFGEF2 |
| Clone | monoclonal |
| Host Species | Rabbit |
| Reactive Species | human, mouse, rat |
| Isotype | IgG |
| Format | unconjugated |
| Size | 100 ul |
| Concentration | 1mg/ml |
| Applications | WB |
| Reviews / Ratings | If you have used this antibody, please help fellow researchers by submitting reviews to pAbmAbs and antYbuddY. |
| Description | Promotes guanine-nucleotide exchange on ARF1 and ARF3 and to a lower extent on ARF5 and ARF6. Promotes the activation of ARF1/ARF5/ARF6 through replacement of GDP with GTP. Involved in the regulation of Golgi vesicular transport. Required for the integrity of the endosomal compartment. Involved in trafficking from the trans-Golgi network (TGN) to endosomes and is required for membrane association of the AP-1 complex and GGA1. Seems to be involved in recycling of the transferrin receptor from recycling endosomes to the plasma membrane. Probably is involved in the exit of GABA(A) receptors from the endoplasmic reticulum. Involved in constitutive release of tumor necrosis factor receptor 1 via exosome-like vesicles; the function seems to involve PKA and specifically PRKAR2B. Proposed to act as A kinase-anchoring protein (AKAP) and may mediate crosstalk between Arf and PKA pathways. |
| Immunogen | A synthetic peptide of human ARFGEF2 |
| Other Names | BIG2; PVNH2; dJ1164I10.1 |
| Gene, Accession # | Gene ID: 10564, UniProt: Q9Y6D5 |
| Catalog # | orb1732294 |
| Price | $345 |
| Order / More Info | ARFGEF2 Antibody from BIORBYT LTD. |
| Product Specific References | n/a |
BIORBYT LTD.
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