TPM1 / Tropomyosin-1 / Alpha Tropomyosin Antibody from BIORBYT LTD.
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| Antigenic Specificity | TPM1 / Tropomyosin-1 / Alpha Tropomyosin |
| Clone | TPM1/4510 |
| Host Species | Mouse |
| Reactive Species | human |
| Isotype | IgG1 |
| Format | unconjugated |
| Size | 100 ug |
| Concentration | n/a |
| Applications | IHC-P |
| Reviews / Ratings | If you have used this antibody, please help fellow researchers by submitting reviews to pAbmAbs and antYbuddY. |
| Description | Tropomyosins are a group of structural proteins. Tropomyosins are present in virtually all eukaryotic cells, both muscle and non-muscle, where they bind actin filaments and function to modulate Actin-myosin interaction and stabilize actin filament structure. Tropomyosin Alpha is encoded by the TPM1 gene, which maps to human chromosome 15q22.2 and undergoes alternative splicing to generate at least four isoforms, including skeletal muscle (isoform 1), smooth muscle (isoform 2), fibroblast/TM3 (isoform 3) and isoform 4. Tropomyosin b is encoded by the TPM2 gene, which maps to human chromosome 9p13.3 and undergoes alternative splicing to generate three isoforms, including skeletal muscle (isoform 1), non-muscle/fibroblast TM36/epithelial TMe1 (isoform 2) and non-muscle (isoform 3). Troponin I binds Tropomyosin at a specific region and the association of Tropomyosin-Troponin with actin filaments may increase the rigidity of actin filaments. Tropomyosin also interacts with caldesmon to regulate smooth muscle contraction. |
| Immunogen | Recombinant full-length protein was used as the immunogen for the Alpha Tropomyosin antibody. |
| Other Names | n/a |
| Gene, Accession # | UniProt: P04268 |
| Catalog # | orb1825421 |
| Price | $764 |
| Order / More Info | TPM1 / Tropomyosin-1 / Alpha Tropomyosin Antibody from BIORBYT LTD. |
| Product Specific References | n/a |
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