PD-L1 / B7-H1 / CD274 Antibody from BIORBYT LTD.
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| Antigenic Specificity | PD-L1 / B7-H1 / CD274 |
| Clone | PDL1/2746 |
| Host Species | Mouse |
| Reactive Species | human |
| Isotype | IgG2b, kappa |
| Format | Protein G purified |
| Size | 100 ug, 20 ug |
| Concentration | n/a |
| Applications | ELISA, FACS, IF, IHC-P, WB |
| Reviews / Ratings | If you have used this antibody, please help fellow researchers by submitting reviews to pAbmAbs and antYbuddY. |
| Description | Engagement of CD28 by B7-1 (CD80) or B7-2 (CD86) in the presence of antigen promotes T-cell proliferation, cytokine production, differentiation of effector T-cells and the induction of BCLX, a promoter of T-cell survival. recruitment of CTLA4 by B7-1 or B7-2, on the other hand, may inhibit proliferation and interleukin-2 (IL-2) production. PD-L1 is 290-amino acid type I transmembrane protein, which is 20% and 15% identical to B7-1 and B7-2, respectively, has immunoglobulin V-like and C-like domains and a 30-amino acid cytoplasmic tail. PD-L1 does not bind CD28, cytotoxic T-lymphocyte A4 or ICOS (inducible co-stimulator). IL-2, although produced in small amounts, is required for the effect of PD-L1 co-stimulation. PD-L2 protein contains a signal sequence, IgV- and IgC-like domains, a transmembrane region and a cytoplasmic region. Constitutive expression of PD-L1 and PD-L2 on parenchymal cells of heart, lung and kidney suggests that the PD-1-PD-L system could provide unique negative signaling to help prevent autoimmune diseases. |
| Immunogen | A portion of amino acids 39-191 from the human protein was used as the immunogen for this PD-L1 antibody. |
| Other Names | n/a |
| Gene, Accession # | UniProt: Q9NZQ7 |
| Catalog # | orb606675 |
| Price | $764 |
| Order / More Info | PD-L1 / B7-H1 / CD274 Antibody from BIORBYT LTD. |
| Product Specific References | n/a |
BIORBYT LTD.
BIORBYT LTD.
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