KDM5C / JARID1C / SMCX Antibody from BIORBYT LTD.
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|---|---|
| Antigenic Specificity | KDM5C / JARID1C / SMCX |
| Clone | PCRP-KDM5C-1A11 |
| Host Species | Mouse |
| Reactive Species | human |
| Isotype | IgG2c |
| Format | unconjugated |
| Size | 100 ug |
| Concentration | n/a |
| Applications | FACS |
| Reviews / Ratings | If you have used this antibody, please help fellow researchers by submitting reviews to pAbmAbs and antYbuddY. |
| Description | SmcX, also known as JARID1C (jumonji, AT rich interactive domain 1C), MRXJ, KDM5C or XE169, is a nuclear protein that contains one ARID domain, one JmjC domain, one JmjN domain and two PHD-type zinc fingers and belongs to the JARID1 histone demethylase family. Expressed ubiquitously with highest expression in brain and skeletal muscle, SmcX functions as a histone demethylase that removes methyl groups from lysine residues on Histone H3, thereby playing a role in the histone code, as well as transcriptional regulation and chromatin remodeling. SmcX binds iron and a-ketoglutarate as cofactors and can recruit histone deacetylases to neuron silencer elements, thus repressing the transcription of neuronal genes. Defects in the gene encoding SmcX are associated with X-linked mental retardation (XLMR), a condition characterized by cognitive impairment and a low IQ. Multiple isoforms of SmcX are expressed due to alternative splicing events. |
| Immunogen | Recombinant full-length human protein was used as the immunogen for the JARID1C antibody. |
| Other Names | n/a |
| Gene, Accession # | UniProt: P41229 |
| Catalog # | orb1822643 |
| Price | $764 |
| Order / More Info | KDM5C / JARID1C / SMCX Antibody from BIORBYT LTD. |
| Product Specific References | n/a |
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