Phospho-CBL (Tyr774) Antibody from BIORBYT LTD.
Search, find, compare suppliers for anti-Phospho-CBL (Tyr774) antibody, protein, ELISA kits.
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|---|---|
| Antigenic Specificity | Phospho-CBL (Tyr774) |
| Clone | monoclonal |
| Host Species | Rabbit |
| Reactive Species | human, rat |
| Isotype | IgG |
| Format | unconjugated |
| Size | 100 ul |
| Concentration | 1mg/ml |
| Applications | IP, WB |
| Reviews / Ratings | If you have used this antibody, please help fellow researchers by submitting reviews to pAbmAbs and antYbuddY. |
| Description | This gene is a proto-oncogene that encodes a RING finger E3 ubiquitin ligase. The encoded protein is one of the enzymes required for targeting substrates for degradation by the proteasome. This protein mediates the transfer of ubiquitin from ubiquitin conjugating enzymes (E2) to specific substrates. This protein also contains an N-terminal phosphotyrosine binding domain that allows it to interact with numerous tyrosine-phosphorylated substrates and target them for proteasome degradation. As such it functions as a negative regulator of many signal transduction pathways. This gene has been found to be mutated or translocated in many cancers including acute myeloid leukaemia. Mutations in this gene are also the cause of Noonan syndrome-like disorder |
| Immunogen | A synthetic phosphopeptide corresponding to residues surrounding Tyr774 of human CBL |
| Other Names | CBL; CBL2; RNF55; E3 ubiquitin-protein ligase CBL; Casitas B-lineage lymphoma proto-oncogene; Proto-oncogene c-Cbl; RING finger protein 55; Signal transduction protein CBL |
| Gene, Accession # | Gene ID: 867, UniProt: P22681 |
| Catalog # | orb1733125 |
| Price | $345 |
| Order / More Info | Phospho-CBL (Tyr774) Antibody from BIORBYT LTD. |
| Product Specific References | n/a |
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